Hyperglycemia, inflammatory response and infarct size in obstructive acute myocardial infarction and MINOCA

Abstract Background Hyperglycemia has been associated with increased inflammatory indexes and larger infarct sizes in patients obstructive acute myocardial infarction (obs-AMI). In contrast, no studies have explored these correlations non-obstructive (MINOCA). We investigated the relationship between hyperglycemia, inflammation size a cohort of AMI that included MINOCA. Methods Patients undergoing coronary angiography 2016 2020 were enrolled. The following markers evaluated: C-reactive protein, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR) neutrophil-to-platelet (NPR). Myocardial was measured by peak high sensitivity troponin I (Hs-TnI) levels, left-ventricular-end-diastolic-volume (LVEDV) left ventricular ejection fraction (LVEF). Results final study population consisted 2450 obs-AMI 239 more prevalent among cases. all hyperglycemic patients—obs-AMI MINOCA—NLR, NPR, LPR markedly altered. Hyperglycemic subjects exhibited higher Hs-TnI (p < 0.001), LVEDV = 0.003) lower LVEF 0.001) compared to normoglycemic ones. Conversely, MINOCA showed trivial damage, irrespective admission glucose levels. Conclusions Our data confirm association elevated sizes. modest regardless